Final answer:
The Cherokee lost much of their land and many were killed, which is encapsulated in option c), highlighting the broader impacts of the Indian Removal Act and the Trail of Tears.
Step-by-step explanation:
The lasting effect of the Cherokee War is most accurately represented by option c): The Cherokee lost much of their land, and many of them were killed. Throughout their interaction with European settlers and later the United States government, the Cherokee faced repeated pressure and violence.
The Indian Removal Act of 1830 led to the forced removal of the Cherokee and other Native American tribes, leading to the infamous Trail of Tears. During this tragic event, around 4,000 Cherokee people died while being forcibly marched from their ancestral lands to what is now Oklahoma.
The Cherokee War and the continued encroachment on their territory eventually culminated in their displacement, highlighting the Intense impacts of colonization and westward expansion on Native American tribes.