Question

Which of the following best describes the role IκBα phosphorylation plays in the signaling pathway and what the modification of IκBα does?

A. IκBα phosphorylation promotes its degradation, allowing NF-κB to translocate into the nucleus and activate gene transcription.

B. IκBα phosphorylation inhibits NF-κB activation by preventing its translocation into the nucleus.

C. IκBα phosphorylation stabilizes NF-κB, enhancing its binding to DNA and promoting gene expression.

D. IκBα phosphorylation has no significant impact on the signaling pathway.

Answer 1

IκBα phosphorylation leads to its degradation, which permits NF-κB to enter the nucleus and activate gene transcription.

Step-by-step explanation:

The role of IκBα phosphorylation within the signaling pathway is critical for the regulation of NF-κB, a transcription factor involved in multiple cellular processes such as immunity, inflammation, and cell survival

When IκBα is phosphorylated, it undergoes conformational changes that lead to its ubiquitination and subsequent degradation. This degradation allows NF-κB, which is normally kept in the cytoplasm by IκBα, to translocate into the nucleus where it can bind DNA and stimulate transcription of target genes. Therefore, the correct answer is A. IκBα phosphorylation promotes its degradation, allowing NF-κB to translocate into the nucleus and activate gene transcription.