Final answer:
The favorable location of Rome on the Mediterranean Sea was a fundamental factor in the city's political and economic dominance due to its strategic position for trade and defense.
Step-by-step explanation:
The most accurate statement regarding the development of Rome is: A. Favorable location on the Mediterranean Sea promoted political and economic dominance. Rome's strategic position on the Mediterranean facilitated trade and travel, and its access to seaports like Ostia was crucial for economic prosperity. The geographic features of Rome, such as its defensible hills and proximity to the Tiber River, provided commercial advantages and opportunities for expansion. Additionally, Rome's location allowed it to act as a conduit for cultural and economic interactions within the Mediterranean basin, particularly between the Greek colonies of southern Italy and various Italian cultures.