Final answer:
The Pueblo Revolt of 1680, led by Popé, is the event where Native Americans resisted Spanish rule and the spread of Christianity in the southwestern United States.
Step-by-step explanation:
The event that corresponds to a Native American resistance to the Spanish and the spread of Christianity in what is today the southwestern United States is the Pueblo Revolt. The Pueblo Revolt of 1680 was led by a Tewa Pueblo religious leader named Popé (also spelled Po'pay) and included various Pueblo people and the Apache tribe. This organized uprising was in response to Spanish religious, economic, and cultural abuses in New Mexico. While the revolt caused the Spanish to flee and allowed nearly twelve years of autonomy for the Pueblo people, the Spanish eventually regained control. Despite this, the revolt had a lasting impact on Spain's colonial policies; they became more lenient, allowing the Pueblo to keep much of their traditional way of life and religious practices.