Final answer:
During a chemical change, bonds are broken or formed, leading to the creation of new molecules with different properties, indicative of a substantial transformation at the molecular level.
Step-by-step explanation:
During a chemical change, what happens to the molecules of a substance is that bonds in the molecules are made or broken to form new molecules. This process is part of a chemical reaction in which one or more substances, the reactants, are transformed into one or more new substances, known as the products. These new molecules have different properties than the original molecules, signifying that a chemical change has occurred. This change often results in a substance with a different melting point, color, taste, and other physical and chemical characteristics than the original substance, and it is typically harder to reverse than a physical change.