Final answer:
In Chapter 1 of 'Of Mice and Men', Lennie is best described as a large, strong man with childlike innocence and a love for soft things.
Step-by-step explanation:
The character description that best matches Lennie in Chapter 1 of Of Mice and Men is (C) A large, strong man with a childlike innocence and a love for soft things. This depiction aligns with John Steinbeck's portrayal of Lennie Small. Lennie is characterized by his immense physical strength and his simple-minded, innocent nature. He has an affinity for tactile sensations, particularly soft objects, which is a recurring theme throughout the novel. Steinbeck contrasts Lennie's imposing size with his mental immaturity, creating a complex and sympathetic character.