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Cross a hemophilia female with a normal male. Why is there a 100% chance of the sons having hemophilia?

A) Males get their X chromosome from their mothers, and both of her chromosomes have the recessive allele for hemophilia.
B) Males get their Y chromosome from their fathers, and this father's Y chromosome has the recessive allele for hemophilia.
C) Males get their X chromosome from their fathers, and this father's X chromosome has the recessive allele for hemophilia.

User Paul Hoang
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Final answer:

There is a 100% chance that the sons will have hemophilia when a hemophilia female is crossed with a normal male as males inherit their X chromosome from their mothers, who has the hemophilia allele on both X chromosomes. Daughters will be carriers but not necessarily affected, as they inherit one normal X from the father.

Step-by-step explanation:

When you cross a hemophilia female with a normal male, there is a 100% chance that the sons will have hemophilia because of the pattern of X-linked recessive inheritance. The correct choice is A) Males get their X chromosome from their mothers, and both of her chromosomes have the recessive allele for hemophilia. This is because hemophilia is an X-linked disorder, and males have only one X chromosome which they inherit from their mother. If the mother has the condition, it means both of her X chromosomes carry the hemophilia allele. Therefore, her sons will, by necessity, inherit an X chromosome with the hemophilia allele from her, resulting in the disease's expression.

On the other hand, daughters will not necessarily be affected because they will inherit one X chromosome from the mother (which has the hemophilia allele) and one from the father (which is normal), potentially making them carriers if the inherited X from the mother carries the recessive gene. Females need two mutated X chromosomes to be hemophilic, but in this case, they will only have one mutated and one normal X chromosome, typically resulting in them being carriers without exhibiting the symptoms of hemophilia.

User Hoetz
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