Final answer:
In the 1500s, Spain expelled both Jews and Muslims as part of a push towards religious uniformity, particularly through the actions of the Spanish Inquisition.
Step-by-step explanation:
In the 1500s, Spain expelled two specific groups of people based on religious grounds. These groups were Jews and Muslims. This expulsion was closely tied to the Spanish Inquisition, which targeted those who did not conform to the Catholic faith.
The decree affecting Jews was issued in 1492, the same year as the final reconquest of Spain from Muslim rule and Christopher Columbus's voyage. Similarly, Muslims were given an ultimatum to convert to Catholicism or leave Spain shortly thereafter. This repression reflected the broader European environment, which was moving towards religious conformity, especially following the Protestant Reformation.