Final answer:
Hernando de Soto aimed to b. conquer and subjugate the indigenous native population, imposing Spanish rule and exploiting their resources. His expedition did not find the expected wealth but resulted in the spread of diseases and loss of native lives.
Step-by-step explanation:
Hernando de Soto's objective with the indigenous native population was to B) conquer and subjugate them, imposing Spanish rule and exploiting their resources. His expedition from 1539 to 1542 explored what is now the southeastern United States, looking for gold.
However, the outcome of the expedition was not successful in terms of finding the expected wealth. Instead, it resulted in the spread of European diseases, leading to the loss of thousands of native lives and the deaths of many explorers, including de Soto himself.