Final answer:
The main differences between the protagonists of 'The Tell-Tale Heart' and 'The Yellow Wallpaper' are the gender of the characters and their experiences with mental health treatment, with the former being male and self-proclaimed sane, and the latter being a woman whose treatment exacerbates her condition.
Step-by-step explanation:
Two key differences between the main characters of The Tell-Tale Heart by Edgar Allan Poe and Charlotte Perkins Gilman's The Yellow Wallpaper are their gender and their mental health treatment. In Poe's work, the unnamed narrator is male and portrays himself as sane despite exhibiting signs of extreme paranoia and ultimately confessing to a murder driven by his hallucinations. In contrast, the female protagonist of The Yellow Wallpaper is a woman undergoing a rest cure for what is hinted to be postpartum depression, and her mental health steadily deteriorates, symbolized by her obsession with the wallpaper in her confinement room.