Final answer:
The quote 'Paranoia can make fools out of people' best fits the theme of 'An Uncomfortable Bed,' showing the extent to which irrational fears can lead to absurd outcomes.
Step-by-step explanation:
The quote that best describes the theme of 'An Uncomfortable Bed' is 'Paranoia can make fools out of people.' This selection captures the essence of the story in which the fear of being pranked leads to irrational behavior, highlighting how paranoia can cloud judgment and prompt absurd actions. The protagonist's elaborate precautions to avoid being the victim of a joke only serve to make him look foolish when it turns out there was no prank to begin with.
Other themes explored in the story include the concept that practical jokes have a price, often costing a friendship, and the notion that true friends are never cruel. However, they are not as central to the narrative as the idea that paranoia drives otherwise sensible people to ridiculous lengths. While it's true that it's better to be paranoid and wrong than oblivious, in the case of the story, being paranoid yields no benefits and merely leads to the protagonist's embarrassment.