Final answer:
The region of Africa most engaged in the Trans-Atlantic slave trade was West Africa, which was the primary source of slaves for European traders.
Step-by-step explanation:
The question posed is related to historical events, specifically the Trans-Atlantic slave trade. The correct answer to which region of Africa was most directly involved is West Africa. This region was the principal source of slaves during the Trans-Atlantic slave trade. European traders built forts and castles along the coast of West Africa and engaged in trade with African groups, exchanging goods for captured people who were then transported across the Atlantic and sold into slavery in the Americas and the Caribbean.
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