Final answer:
Audrey's brothers had 5/64 of the cake.
Step-by-step explanation:
Audrey ate 1/16 of the cake, so there were 15/16 of the cake left.
Her school friends ate 3/4 of the cake, so they consumed (3/4)*(15/16) = 45/64 of the cake.
This means there were (15/16) - (45/64) = 15/64 of the cake left.
Audrey's two brothers together ate 1/3 of the remaining pieces of the cake, so they consumed (1/3)*(15/64) = 5/64 of the cake.
Therefore, Audrey's brothers had 5/64 of the cake.