Final answer:
The second cross of an F2 female with an F1 male in genetics is known as a backcross, which is used to explore the inheritance patterns and determine genetic makeup.
Step-by-step explanation:
The second cross involving an F2 female with an F1 male in the context of genetics is referred to as a backcross. A backcross is a breeding experiment in which a hybrid organism is crossed with one of its parents or with the genetically equivalent organism. This technique helps to determine the genetic makeup of the hybrid by examining which traits are passed on from the initial generation (F1) to the subsequent generation (F2) and can reveal the dominance or recessiveness of alleles.