Question

Effect in the amino acid chain - missense, nonsense, silent and neutral - that occurred in a sequence.

Identify what type of mutation described below:
In the DNA level a healthy non mutated codon reads TTC, however after the *nutation occurs the mutated codon in the DNA level reads as ATC.

A. Missense Mutation
B. Neutral Mutation
C. Silent Mutation
D. Nonsense Mutation

Answer 1

The mutation in the DNA sequence from TTC to ATC is a missense mutation because it results in the substitution of phenylalanine with isoleucine, which are different amino acids.

Step-by-step explanation:

In the given sequence, the original DNA codon is TTC, which codes for the amino acid phenylalanine. After the mutation, the codon changes to ATC. This results in a substitution of one base pair. Considering the genetic code, ATC codes for the amino acid isoleucine. Since the new codon codes for a different amino acid, this is an example of a missense mutation.

A missense mutation has the potential to affect protein function, depending on the properties of the original and substituted amino acids. In this case, phenylalanine is a nonpolar, hydrophobic amino acid, whereas isoleucine is also nonpolar and hydrophobic. Although they are chemically similar, they are different amino acids, which means the mutation could either be a conservative missense mutation (if it does not impact protein function significantly) or a nonconservative missense mutation (if it alters protein function significantly).