Final answer:
The abnormality that is not abnormal in a karyotype is too many of chromosome number 21. This abnormality is associated with Down Syndrome, which is identified by a third copy of chromosome 21.
Step-by-step explanation:
The abnormality that is not abnormal is a. Too many of chromosome number 21. This abnormality is associated with Down Syndrome, which is identified by a third copy of chromosome 21. The other abnormalities mentioned in the options, such as too few X chromosomes, no Y chromosome, and a whole extra set of 23 chromosomes, are all considered abnormal in a karyotype.