Final answer:
Agriculture led to the formation of tribes with unique immunity profiles, which were challenged by the introduction of new diseases during European contact, causing epidemics.
Step-by-step explanation:
If we select agriculture, tribe, and immunity as key terms, there is a significant historical relationship between them. Agriculture allowed Indigenous peoples to settle and form tribes with complex social structures. However, their immunity was concentrated on the pathogens present within their own environment. When Europeans arrived with new diseases, many indigenous tribes had no natural immunity, leading to devastating epidemics.