The cells undergoing the cell cycle 1.Securin remains stable, inhibiting separase and preventing chromosome separation during anaphase.3) These cells would not be able to undergo Anaphase.5) These cells would not be able to degrade mitotic cyclins is correct.
The APC/C is a critical enzyme responsible for regulating the cell cycle, particularly during mitosis. It targets key proteins for degradation, including securin and mitotic cyclins.
Securin is an inhibitor of separase, an enzyme that cleaves the sister chromatid cohesion complex, allowing for their separation during anaphase. Mitotic cyclins, on the other hand, drive the progression of mitosis.
If the APC/C is inhibited, securin would not be degraded, leading to the inhibition of separase and preventing chromosome separation during anaphase.
Additionally, mitotic cyclins would not be degraded, causing the cells to remain in mitosis indefinitely. As a result, these cells would not be able to exit mitosis and proceed to the next stage of the cell cycle.
Question
A new small molecule drug inhibits the function of the APC/C. If this drug were applied to cells undergoing the cell cycle, what do you think would be the result? Check all that apply.
1) Securin would not be destroyed in these cells.
2) Separase would be constitutively active (always on) in these cells.
3) These cells would not be able to undergo Anaphase.
4) These cells would not be able to undergo Prophase.
5) These cells would not be able to degrade mitotic cyclins.
6) These cells would not be able to exit mitosis.