Question

pcp and ketamine increase serotonin neurotransmission by doing which of the following? select one or more: activating 5-ht2a receptors increasing release of serotonin acting as agonists at d2 receptors acting as antagonists at nmda receptors

Answer 1

PCP and ketamine act as antagonists at NMDA receptors, which can indirectly affect serotonin neurotransmission, but do not act directly on serotonin receptors or as D2 agonists.

Step-by-step explanation:

PCP and ketamine are known to interfere with neurotransmitter systems in the brain, with a particular effect on the NMDA receptor, which is one of the glutamate receptors. These substances act as antagonists of the NMDA receptor, which can result in increased neurotransmission of serotonin. However, it is important to note that PCP and ketamine are not primarily serotonin agonists; they do not directly activate the 5-HT (serotonin) receptors nor act as agonists at dopamine D2 receptors. Their mechanism involves inhibiting the NMDA receptor, which can indirectly affect serotonin levels, potentially leading to increased release or altered serotonin dynamics.