The answer is 0.000005960464775390625
Each dosage is q=100% and is eliminated 75%, so after 4 hours the concentration is 25% of the original dosage.
After 4 hours the concentration is q(1-0.75)=100(1-0.75)=25%
After 8 hours the concentration is 100(1-0.75)^2=6.25%
After 12 hours the concentration is 100(1-0.75)^3=1.5625%
After 16 hours the concentration is 100(1-0.75)^4=0.390625%
After 20 hours the concentration is 100(1-0.75)^5=0.09765625%
After 24 hours the concentration is 100(1-0.75)^6=0.0244140625%
After 28 hours the concentration is 100(1-0.75)^7=0.006103515625%
After 32 hours the concentration is 100(1-0.75)^8=0.00152587890625%
After 36 hours the concentration is 100(1-0.75)^9=0.0003814697265625%
After 40 hours the concentration is 100(1-0.75)^10=0.000095367431640625%
After 44 hours the concentration is 100(1-0.75)^11=0.00002384185791015625%
After 48 hours the concentration is 100(1-0.75)^12=0.000005960464775390625%
The concentration of the drug after 48 hours is 100(1-0.75)^12=0.000005960464775390625%
So the answer is 0.000005960464775390625