Final answer:
The statement regarding the acquisition of land being the central motivator for early U.S. Indian policy is true. Land acquisition was a key part of the United States' expansionist goals, significantly shaping treaties and laws pertaining to Native American tribes.
Step-by-step explanation:
The statement that acquisition of land was the most important motivating factor in the formulation of early U.S. Indian policy is True. Throughout the early history of the United States, policies towards Indigenous peoples were frequently centered around the expansion of territory and resources for colonial and then later, American settlers. Treaties, acts, and forced removals, such as the Indian Removal Act of 1830, were all methods used to acquire land from Native American tribes. This acquisition often came at great cost to these tribes, including loss of life, culture, and their ancestral homelands.