Final answer:
Polar receptors cannot easily penetrate the plasma membrane. Instead, they interact with membrane receptor proteins on the cell surface and activate secondary messengers.
Step-by-step explanation:
Polar receptors face challenges in penetrating the plasma membrane due to their polar nature. They cannot easily pass through the lipid bilayer of the membrane. Instead, they interact with membrane receptor proteins on the cell surface, which can lead to various responses inside the cell. This includes the activation of secondary messengers through the interaction of the receptor with a G-protein, which initiates a series of intracellular reactions.