Final answer:
To prevent the spread of Clostridium difficile, important transmission-based precautions include contact precautions such as the use of personal protective equipment and strict hand hygiene.
Step-by-step explanation:
To prevent the transmission of Clostridium difficile, it is crucial for a home health care nurse to teach the client's family about taking certain transmission-based precautions. The correct precaution for this infection is C) Contact precautions. Contact precautions include using personal protective equipment such as gloves and gowns, washing hands meticulously with soap and water, and ensuring the proper disinfection of surfaces and equipment that might have come in contact with contaminants. Given that C. difficile can form endospores and survive for extended periods under harsh conditions, these measures are vital in preventing its spread.