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Marci has been started on a TB regimen. Because isoniazid (INH) may cause peripheral neuropathy, you consider ordering which of the following drugs prophilactically?

a. Pyroxidine
b. Thiamine
c. Probiotic
d. Phytonadione

1 Answer

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Final answer:

To prevent peripheral neuropathy caused by isoniazid (INH) in a TB treatment regimen, it is advisable to order pyridoxine (vitamin B6) prophylactically. Pyridoxine helps to offset the potential deficit caused by INH, thereby reducing the risk of neuropathy.

Step-by-step explanation:

Marci has been started on a TB regimen and to mitigate the risk of peripheral neuropathy caused by isoniazid (INH), it is recommended to prophylactically order pyridoxine (vitamin B6). INH can cause a deficiency of vitamin B6 because of its structural resemblance to the vitamin. Pyridoxine is essential for the prevention and treatment of peripheral neuropathy, a potential side effect associated with INH treatment. Other options such as thiamine, probiotics, and phytonadione are not directly related to the prevention of INH-induced peripheral neuropathy. Therefore, administering pyridoxine alongside INH is a common practice to reduce the risk of this side effect, improving the safety of tuberculosis treatment protocols.

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