Final answer:
An inosine at the first position of an anticodon does not typically pair with a cytosine at the third position of a codon, according to the wobble hypothesis which allows for efficient protein synthesis.
Step-by-step explanation:
Based on the wobble hypothesis, an inosine (I) at the first position of an anticodon does not pair with a cytosine (C) at the third position of the codon. In the context of mRNA codon-anticodon interaction, the presence of an inosine in the anticodon allows for wobbling, where the inosine can hydrogren bond with uracil (U), adenine (A), or cytosine (C); however, it most commonly does not pair with cytosine according to some research findings. This aspect of the genetic code ensures efficient protein synthesis despite having fewer tRNAs than codons for each amino acid.