Final answer:
The consequences of an increase in the Michaelis-Menten constant (Km) are related to the rate of reaction in enzymatic reactions.
Step-by-step explanation:
A high Km value indicates weak binding between the enzyme and the substrate, while a low Km value indicates strong binding. This means that with a higher Km, the enzyme requires a higher concentration of substrate to reach half of its maximum velocity (Vmax). On the other hand, with a lower Km, the enzyme can reach half of its maximum velocity with a lower concentration of substrate.
When the Km increases, it signifies a decrease in the affinity of the enzyme for its substrate, resulting in a slower reaction rate. Conversely, when the Km decreases, it indicates an increase in the affinity of the enzyme for its substrate, leading to a faster reaction rate.
Therefore, an increase in Km generally results in a decrease in the efficiency of the enzyme-substrate interaction and a slower rate of reaction.