Question

Which of the following is mismatched?

a. immunoglobulin light chain: VJ
b. T-cell receptor α chain: VJ
c. immunoglobulin heavy chain: VJ
d. T-cell receptor β chain: VDJ
e. None of the above is mismatched

Answer 1

None of the options presented are mismatched. Each correctly identifies the gene segment recombination pattern for the immunoglobulin light chain, T-cell receptor α chain, immunoglobulin heavy chain, and T-cell receptor β chain.

Step-by-step explanation:

Each option correctly pairs the gene segment recombination pattern with the respective chain of the immune system's receptors. Specifically:

• Immunoglobulin light chain (VJ): The light chain of immunoglobulins undergoes gene rearrangement where variable (V) and joining (J) segments are combined.
• T-cell receptor α chain (VJ): Similar to B-cells, T-cell receptor alpha chains also use V and J gene segments for creating diversity.
• Immunoglobulin heavy chain (VDJ): The heavy chain of immunoglobulins involves variable (V), diversity (D), and joining (J) gene segments in its rearrangement.
• T-cell receptor β chain (VDJ): T-cell receptor beta chains also use V, D, and J gene segments for antigen receptor diversity.

These gene rearrangements contribute to the diversity of the immune response by allowing a multitude of unique antigen-binding sites for B-cell receptors (BCRs) and T-cell receptors (TCRs).