Final answer:
No, TLRs do not modify their specificity throughout the immune response.
Step-by-step explanation:
TLRs modify their specificity throughout the immune response called affinity maturation.
This statement is false.
Affinity maturation refers to the process by which B cells in the immune system improve the specificity and binding strength of their antibody receptors. During affinity maturation, B cells undergo somatic hypermutation and clonal selection, leading to the production of high-affinity antibodies that can more effectively neutralize pathogens. TLRs, on the other hand, are proteins localized on the cell membrane of immune cells, and they recognize molecules characteristic of invaders. They do not modify their specificity throughout the immune response.