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Which Fc receptor is responsible for triggering the release of histamine, proteases, and other inflammatory signals from IgE?

A. Fcα receptor
B. Fcε receptor
C. Fcɣ receptor
D. Neonatal Fc receptor
E. Polymeric immunoglobulin receptor (pIgR)

User Aracelis
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1 Answer

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Final answer:

The Fcε receptor is responsible for triggering the degranulation of mast cells, leading to the release of histamine and other inflammatory mediators when Ige antibodies bound to it encounter their specific allergen.

Step-by-step explanation:

The Fc receptor responsible for triggering the release of histamine, proteases, and other inflammatory signals from Ige is the Fcε receptor. This receptor is specific to the Fc region of Ige antibodies, which are associated with allergies and anaphylactic responses. When allergen specific Ige antibodies are bound to the Fcε receptor on mast cells and the specific allergen binds to the Ige, cross-linking of Ige occurs, leading to the degranulation of mast cells and the release of inflammatory mediators such as histamine.

User Dbaltor
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