Final answer:
Lung cancer is the chronic disease most closely associated with tobacco use, and smoking is a major cause of many types of cancers and chronic diseases.
Step-by-step explanation:
The chronic disease most closely associated with tobacco use is c) Lung cancer. Smoking is the major cause of chronic respiratory disease and has been identified as the leading cause of preventable death in the United States. The Centers for Disease Control and Prevention (CDC) states that tobacco use is "the single most important preventable risk to human health in developed countries and an important cause of [early] death worldwide." In addition to lung cancer, smoking is known to cause various other types of cancers and chronic diseases, including heart disease, pneumonia, and chronic obstructive pulmonary disease (COPD).