Question

Where would you most likely find a TLR that recognizes RNA?

A. On the cell surface
B. In the endosome/lysosomes
C. In the nucleus
D. In the mitochondria
E. In the ER

Answer 1

A Toll-like receptor (TLR) that recognizes RNA would most likely be found in the endosome/lysosomes, as these intracellular compartments are responsible for detecting viral or microbial RNA threats.

Step-by-step explanation:

You would most likely find a Toll-like receptor (TLR) that recognizes RNA in the endosome/lysosomes. TLRs are a class of proteins that play a key role in the immune system by detecting foreign substances and signalling for an immune response. Specifically, TLRs that recognize nucleic acids such as RNA tend to be located intracellularly, particularly within endosomal or lysosomal compartments, where they can best identify viral or other microbial RNA as a threat. In contrast, TLRs on the cell surface are more commonly involved in the recognition of extracellular pathogens.