Final answer:
Indomethacin acts as a tocolytic by inhibiting the production of prostaglandins, which in turn reduces uterine contractions and delays premature labor. It is used in short-term management of preterm labor due to potential adverse effects on the fetus.
Step-by-step explanation:
How Indomethacin Acts as a Tocolytic
Indomethacin is a nonsteroidal anti-inflammatory drug (NSAID) that works as a tocolytic by inhibiting the production of prostaglandins. Prostaglandins are substances that induce inflammation and can stimulate uterine contractions. By blocking the enzyme cyclooxygenase, Indomethacin reduces the synthesis of prostaglandins, thereby relaxing the uterus and potentially delaying premature labor.
Indomethacin is often used in the management of preterm labor because it can effectively cross the placental barrier and reach the fetus, providing benefits in situations where other tocolytics may not be appropriate.
However, the use of Indomethacin as a tocolytic is generally limited to short-term treatment due to potential adverse effects, such as constriction of the fetal ductus arteriosus and reduced amniotic fluid volume. The risk and benefits must be carefully considered by healthcare professionals when deciding to use this medication in pregnant women.