Final answer:
The statement about virus replication is true in the biological context; viruses replicate by infecting a host cell and using its machinery to produce new viruses.
Step-by-step explanation:
The statement in the question - A virus self-replicates on the host computer and spreads to other computers by itself - is True, with some clarification needed. A virus in the biological context does indeed replicate itself, but it does so within a host cell, not a computer.
It cannot reproduce independently, as it lacks the necessary cellular machinery. Viruses infect adjacent cells and repeat the replication cycle after they have utilized the host cell's machinery and metabolism to produce new copies of themselves. During the final stage of viral replication, the new virions are released into the host organism, where they can find new cells to infect and continue the cycle. This process is true for all life forms, from humans to fungi.