Final answer:
The replisome is a protein complex involved in DNA replication and consists of DNA pol III holoenzyme, primase, helicase, as well as additional proteins such as clamp proteins and single-stranded binding proteins, which makes 'all of the above' the correct composition.
Step-by-step explanation:
The replisome is a complex of multiple proteins and enzymes involved in the process of DNA replication. It consists of several key components which include the DNA pol III holoenzyme, primase, helicase, clamp proteins, and single-stranded binding proteins. Therefore, when referring to the replisome composition, the correct answer is all of the above. DNA pol III holoenzyme is the main enzyme required for DNA synthesis, and it is composed of several subunits (α, α, β, and β'), which comprise the polymerase core enzyme, with a fifth subunit (σ) involved in transcription initiation. Helicase unwinds the DNA double helix, primase synthesizes RNA primers, and the DNA pol III holoenzyme extends the DNA strand from these primers.