Final answer:
Titin is not known for associating actin microfilaments with the plasma membrane, unlike other proteins such as filamin, α-actinin, talin, and vinculin, which interact with actin in such associations.
Step-by-step explanation:
The molecule not known for associating actin microfilaments with the plasma membrane is titin. Actin microfilaments are crucial for maintaining cell shape, and enabling cell movement, and are involved in cell division processes such as cytokinesis. Proteins like filamin and α-actinin are known to interact with actin by crosslinking or bundling actin filaments, contributing to the structure and contractility of the cell's cytoskeleton.
On the other hand, titin is associated more with muscle sarcomeres and elasticity rather than with actin-membrane associations. The transmembrane protein complex integrin and intracellular proteins like talin and vinculin are more directly involved in linking actin filaments to the cell membrane at structures known as focal adhesions.
Therefore, when discussing the association of actin microfilaments with the plasma membrane, titin is not typically involved in this function.