Question

Multiple basic elements are found in the promoter region of a gene (DNA). Minus 1 nucleotide is ____________

-the nucleotide at which translation is initiated

-the nucleotide preceding the one at which translation is initiated

-the nucleotide to which the RNA polymerase binds

-the nucleotide preceding the one at which transcription is initiated

-the nucleotide at which transcription is initiated

Answer 1

In DNA transcription, the minus 1 nucleotide is the one preceding the initiation site of transcription, not translation.

Step-by-step explanation:

The question revolves around the concept of the promoter region in DNA, specifically the designation of the nucleotide minus 1 relative to the site of transcription initiation. In the context of DNA transcription, the nucleotide pair that corresponds to the initiation site from which the first 5' mRNA nucleotide is transcribed is called the +1 site, or the initiation site. Nucleotides preceding this initiation site are designated with negative numbers and are upstream nucleotides. Hence, the correct answer is that the minus 1 nucleotide is the nucleotide preceding the one at which transcription is initiated.