Final answer:
High sugar intake can lead to insulin resistance, metabolic syndrome, and altered lipid metabolism.
Step-by-step explanation:
The high sugar intake can have effects on glucose transporter and weight-regulating hormones in mice and humans. One of the concepts related to this is insulin resistance, which occurs when target cells do not respond to normal amounts of insulin. This leads to cells not taking up glucose and elevated blood glucose levels. Another concept is metabolic syndrome, which is a cluster of conditions that includes high blood sugar levels, high blood pressure, and abnormal cholesterol levels. Lipid metabolism is also affected by high sugar intake, as it can lead to increased fatty acid synthesis.