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The human oral LD50 for arsenic is 15mg/kg and you weigh 80kg. Should you be concerned if you ingest 1.5g? Why or why not? Explain in detail - show calculations to prove your response

User Rodalm
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Final answer:

Yes, matter of concern, ingesting 1.5g of arsenic should be a cause for concern for an individual who weighs 80kg because the dose of 18.75mg/kg exceeds the LD50 of 15mg/kg, indicating that the amount ingested is potentially lethal.

Step-by-step explanation:

The student is asking whether the ingestion of 1.5g of arsenic is a cause for concern if they weigh 80kg, considering the oral LD50 for arsenic is 15mg/kg. The LD50 is the lethal dose for 50% of the population tested, often determined through animal testing.

To calculate whether 1.5g is a toxic dose for an individual weighing 80kg, we convert the mass (1.5g) into milligrams (1500mg) and then divide by the individual's body weight in kilograms (80kg).

This results in a dose of 18.75mg/kg, which is higher than the LD50 of 15mg/kg. Therefore, ingesting 1.5g of arsenic is above the LD50 and is a cause for concern, as the dose is likely lethal.

Calculation:
Dose (mg/kg) = Amount ingested (mg) / Body weight (kg)
Dose (mg/kg) = 1500mg / 80kg

= 18.75mg/kg

User Sorig
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