Final answer:
Patients with CLL cells expressing a biologically significant number of IgVH mutations more frequently have Agammaglobulinemia, Severe combined immunodeficiency (SCID), HIV/AIDS, or Chronic granulomatous disease.
Step-by-step explanation:
Patients with CLL cells expressing a biologically significant number of IgVH mutations more frequently have:
- Agammaglobulinemia
- Severe combined immunodeficiency (SCID)
- HIV/AIDS
- Chronic granulomatous disease
IgVH mutations refer to mutations in the immunoglobulin heavy chain variable region genes. These mutations can affect the function of B cells, leading to various immune disorders. In the case of CLL (Chronic Lymphocytic Leukemia), patients with a higher number of IgVH mutations tend to have a worse prognosis compared to those with fewer mutations.