Question

Copy number variations may involve which of the following?

Multiple select question.
a) Translocations
b) Deletions
c) Duplications
d) Inversions

Answer 1

Copy number variations can involve deletions, duplications, translocations, and inversions which are all types of chromosomal mutations that can significantly impact an organism's genetic makeup and overall health.

Step-by-step explanation:

Copy number variations (CNVs) are significant alterations in the DNA of a genome that can lead to various genetic disorders or phenotypical changes. CNVs may involve a range of chromosomal mutations, which include:

• Deletions - where a segment of a chromosome is lost, often leading to a genetic imbalance which can be lethal to a diploid organism.
• Duplications - where a segment of a chromosome is repeated, potentially causing physical and mental abnormalities.
• Translocations - a type of mutation where a large segment of one chromosome breaks off and attaches to a different chromosome, with effects that depend on the positions of the involved genes.
• Inversions - where a piece of a chromosome breaks off, flips around, and reattaches, potentially leading to the production of aneuploid gametes if it affects meiotic processes.

Inversions and translocations do not typically lead to the loss of genetic material, but they can be problematic if breakpoints occur in the middle of essential genes or during reproduction.