Final answer:
The main function of eIF4E during translation is to bind to the 5' cap of mRNA and recruit the ribosome to initiate translation. GTP hydrolysis is necessary for the proper formation of the initiation complex and the binding of the large 60S ribosomal subunit.
Step-by-step explanation:
The main function of eIF4E during translation is to bind to the 5' cap of mRNA and recruit the ribosome to initiate the translation process. It acts as a bridge between the mRNA and the ribosome. If GTP cannot be hydrolyzed, the initiation complex cannot form properly and translation is impeded. This is because GTP hydrolysis is necessary for the release of the initiation factors and for the binding of the large 60S ribosomal subunit.