Final answer:
Chediak-Higashi syndrome is characterized by albinism, immunodeficiency, and issues with blood clotting due to abnormal cellular granules, leading to increased infections and neurological problems.
Step-by-step explanation:
Disease Characteristics of Chediak-Higashi Syndrome
Chediak-Higashi syndrome is a rare genetic disorder characterized by albinism (partial lack of pigmentation in the skin, hair, and eyes), immunodeficiency leading to increased susceptibility to infections, and problems with blood clotting. One of the hallmark features of this condition is the presence of large granules in white blood cells and other types of cells. These granules result from the abnormal fusion of lysosomes and other cytoplasmic granules. The disease also causes neurologic problems like neuropathy. People with Chediak-Higashi syndrome often have a lighter skin tone than other family members and may experience recurrent infections, bruising, bleeding, and other symptoms related to the immune and nervous system dysfunctions. Additionally, during the accelerated phase of the disease, patients may experience a severe form of inflammation throughout the body that can be life-threatening. This phase is marked by an overactivation of immune cells, leading to extensive tissue damage.