Question

In Williamson ether synthesis what do you want the substrate to be

Answer 1

The substrate used in Williamson ether synthesis depends on the desired reaction, whether it is SN2, E2, SN1, or E1.

Step-by-step explanation:

In Williamson ether synthesis, the substrate used is an alcohol that contains a leaving group. This leaving group is typically an alkyl halide or a sulfonate ester. The choice of the substrate depends on the desired reaction, whether it is SN2, E2, SN1, or E1.

For SN2: Primary or methyl substrates are preferred.

For E2: Tertiary substrates are preferred.

For SN1 and E1: Tertiary and secondary substrates can both react, while primary substrates usually do not react.