Final answer:
Infusing vancomycin over at least 60 minutes is essential when treating MRSA to avoid Red Man syndrome. Changing the IV site with each dose is unnecessary unless complications arise, and NSAIDs should be avoided due to increased risk of kidney damage.
Step-by-step explanation:
A nurse preparing to administer IV vancomycin to a client with methicillin-resistant Staphylococcus aureus (MRSA) should plan to take certain precautions. Among those, infusing the medication over at least 60 minutes is critical. This precaution is due to the risk of Red Man syndrome, a reaction that can occur with rapid infusion of vancomycin. Slow administration helps minimize this risk, providing a safer treatment experience for the patient. The nurse does not need to change the IV site with each new dose unless there are indications of thrombophlebitis or other complications. Urine discoloration is not expected with vancomycin, and co-administration with NSAIDs is not recommended due to their nephrotoxic potential which can increase the risk of kidney damage.