Question

The clinical progression of Becker muscular dystrophy is typically much slower than that of Duchenne muscular dystrophy. This is usually the result of

A. gain-of-function mutations in the Duchenne form; loss-of-function mutations in the Becker form
B. in-frame deletions or insertions in the Becker form; frameshift deletions or insertions in the Duchenne form
C. missense mutations in the Becker form; nonsense mutations in the Duchenne form
D. mutations at two distinct loci for these two forms of muscular dystrophy
E. nonsense mutations in the Becker form; missense mutations in the Duchenne form

Answer 1

The slower progression of Becker muscular dystrophy compared to Duchenne muscular dystrophy is due to in-frame deletions or insertions in the Becker form and frameshift deletions or insertions in the Duchenne form, affecting how the dystrophin protein is produced and functions.

Step-by-step explanation:

The clinical progression of Becker muscular dystrophy is typically much slower than that of Duchenne muscular dystrophy. This is usually the result of in-frame deletions or insertions in the Becker form; frameshift deletions or insertions in the Duchenne form. In other words, the mutations in the dystrophin gene for patients with Becker muscular dystrophy often result in an abnormal, but partially functioning dystrophin protein, whereas the mutations for patients with Duchenne muscular dystrophy typically result in a complete absence of the dystrophin protein, leading to a more severe clinical presentation.