Final answer:
Phosphorylating proteins like CDC6, ORC2, ORC1, and CDT1 during the S phase is crucial for controlling the timing and fidelity of DNA replication, which maintains genetic integrity and prevents genomic disorders.
Step-by-step explanation:
We might want to phosphorylate CDC6, ORC2, ORC1, and CDT1 during S phase of replication because phosphorylation is a regulatory mechanism that can activate or deactivate proteins involved in DNA replication. During the S phase, cells must ensure that DNA replication is precise to maintain genetic integrity. Proteins like CDC6, ORC1, ORC2, and CDT1 are important for the initiation and regulation of this replication process.
By phosphorylating these proteins, the cell can modulate their activity, which is crucial to controlling the timing and the fidelity of DNA replication. Phosphorylation might prevent re-replication of the same stretch of DNA, hence ensuring that each segment of DNA is replicated only once per cell cycle. This is critical for maintaining genomic stability and preventing genomic disorders.