Final answer:
During an infection, a systemic temperature increase (c) is an immune response that does not result from antibody-antigen interactions, whereas other options like B cell proliferation and antibody secretion are specifically tied to antibody production.
Step-by-step explanation:
The immune response includes both specific mechanisms, such as the production of antibodies by B cells, and non-specific mechanisms, such as fever. During an infection, one of the non-antibody related defenses that the body utilizes is a systemic temperature increase (c). This is part of the innate immune response and can hinder the replication of pathogens or activate other immune functions. Unlike B cell proliferation (a), aggregation of viral particles (b), and antibody secretion (d), the increase in body temperature is a non-specific defense that does not directly involve the activity of antibodies but rather is a systemic reaction to infection.