Final answer:
Major Issue Management typically employs Governance Risk and Control capabilities to comply with regulations, and assess, and manage risks.
Step-by-step explanation:
Major Issue Management typically uses Governance Risk and Control capabilities. These are designed to ensure that an organization complies with internal and external policies and regulations, assesses risks systematically, and manages those risks effectively.
From the provided options, Targeted Communications, Asset Management, and Record Producers are also crucial organizational capabilities but are not specifically known for managing major issues. Governance Risk and Control, however, directly relates to managing wide-scale and significant issues that can impact an entire organization.