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What binds to the ORC to assemble the prereplication complex that is competent to initiate replication?

a. the ORC factors
b. licensing factors
c. competence factors
d. initiating factors
e.enlisting factors

1 Answer

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Final answer:

The licensing factors are the components that bind to the Origin Recognition Complex (ORC) to assemble the prereplication complex in eukaryotes, enabling the initiation of DNA replication.

Step-by-step explanation:

The component that binds to the Origin Recognition Complex (ORC) to assemble the prereplication complex that is competent to initiate replication in eukaryotes is known as the licensing factors.

In eukaryotic cells, transcription factors and a range of additional proteins are required to begin the process of transcription. Unlike in prokaryotes, where a simple σ factor aids in the binding of RNA polymerase to its promoter, eukaryotes utilize a complex assembly of transcription factors to recruit RNA polymerase II. These basal transcription factors are denoted as TFII (Transcription Factor/polymerase II) followed by a letter such as A, B, C, and so on. An essential player in this complex is TFIID, which consists of the TATA-binding protein (TBP) among others.

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