Question

What established a previously unsuspected link between DNA repair and transcription?

a. RNA synthesis was found to be instrumental in DNA repair.
b. A small subset of RNAs was found to be required for DNA repair.
c. Two subunits of a transcription factor were found to be helicases that were responsible for unwinding DNA during DNA repair.
d. RNases were essential for the process.

Answer 1

Transcription Coupled Repair (TCR) is the mechanism that links DNA repair and transcription. During transcription, if an RNA polymerase encounters damaged DNA, it stalls and enables repair by coupling proteins. TCR ensures accurate transcription and repair of damaged DNA.

Step-by-step explanation:

Transcription Coupled Repair (TCR) is the mechanism that established a previously unsuspected link between DNA repair and transcription. During transcription, if an RNA polymerase encounters a DNA lesion or damaged DNA, it can stall. This allows coupling proteins to reach the stalled polymerase and enable repair. TCR is an essential process that ensures the accurate transcription and repair of damaged DNA.